Clinical Trials

At Northern Westchester Hospital, we are committed to providing leading-edge treatments and clinical trials close to home.  Our patients can benefit from major medical advancements previously found in big city hospitals, now in the comfort of our own community.   

Contact Us today about our Clinical Trials

Click on a link below to view clinical trials at Northern Westchester Hospital:

Cancer Studies

We continue to expand the availability of clinical trials in Westchester, New York and Fairfield, CT.  For more information on Northern Westchester Hospital Clinical Trials, click CONTACT US on the left, or call the Clinical Trials Director, Dr. Joshua Fink, at 914.666.1366

For additional information about clincal trials you can also visit  www.clinicaltrials.gov.  Find FAQs about clinical trials at

http://clinicaltrials.gov/ct2/info/understand

 

Get to know our services... take a virtual tour of NWH.  Visit our blog, to read posts by our clinical trials investigators:  nwhc.net/blog.


Breast Cancer Clinical Trial New York

Dana-Farber Young and Strong CLOSED to new enrollment

What:  The Dana-Farber Young and Strong Program focuses on the needs of young women who have been diagnosed with breast cancer.  This is an educational and supportive study and does not include any medications. 

Who:  Women between the ages of 18 and 45 who have been diagnosed with stage I, II or III breast cancer within the last three months.

Why:  The purpose of this program is to address the gaps in care for young women with breast cancer as part of a larger effort to better understand breast cancer and to improve the care and outcomes for our younger patients.  This study examines whether educational interventions focusing on issues unique to young women with breast cancer, combined with healthy lifestyles, can help to improve the care of young breast cancer patients. The investigators believe that concerns related to fertility, including body image, sexual dysfunction, and physical activity, can be addressed early in order to improve the satisfaction of care and quality of life for young women.
 

NSABP B47

What:  The NSABP B47 study is a trial of adjuvant therapy comparing chemotherapy alone to chemotherapy plus trastuzumab in women with node-positive or high-risk node-negative HER2-low-invasive breast cancer.

Who:  This study is designed for women who are 18 years or older that are not pregnant or nursing. To be eligible, the patient must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy) (patients who have had a nipple-sparing mastectomy are eligible).  

Why:  Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) and giving chemotherapy after surgery may kill more tumor cells. Monoclonal antibodies, such as trastuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread and others find cancer cells and help kill them or carry cancer-killing substances to them. It is not yet known whether combination chemotherapy is more effective with trastuzumab in treating breast cancer. The purpose of this study is to determine if adding a targeted therapy, trastuzumab, to standard treatment with chemotherapy for early stage, HER2-low breast cancer, will prevent breast cancer from returning.

 

MTF-13-02

What: The MTF-13-02 study is an aesthetic trial and a patient reported outcome trial for those who are undergoing Tissue Expander Breast Reconstruction utilizing a Flex Pliable HD skin graft after a mastectomy (unilateral or bilateral) for therapeutic or prophylactic reasons.  Each patient will be in the study for 90 days.  This study is limited to enrollment of 30 patients.

Who: This is a pilot study designed for women who are 18 years or older who are scheduled to undergo post-mastectomy tissue expander breast reconstruction.

Why: This study is being done because surgeons are trying to continually improve their patient's experience when a patient chooses to undergo breast reconstruction using tissue expanders. Tissue expanders are special balloons, which are placed in the breast at the time of your mastectomy. Their advantage is to act—along with the acellular dermal matrix—to increase the overall amount of tissue available to reconstruct your breast.

 

Paloma-2 (Formerly A5481008)

What: The Paloma-2 study is a randomized, multicenter, double-blind Phase 3 study of Letrozole plus PD-0332991 versus Letrozole plus Placebo for the treatment of postmenopausal women with ER(+), HER2(-) Breast Cancer who have not received any prior systemic anti-cancer treatment for advanced disease.

Who: This study is designed for postmenopausal women who are 18 years or older with ER(+), HER2(-) locoregionally recurrent or metastatic disease and will be candidates to receive Letrozole as first-line treatment for their advanced disease.

Why: This study is being done to confirm the clinical benefit and superiority of the combination of PD-0332991 and Letrozole compared to Letrozole and Placebo in postmenopausal women with ER(+)/HER2(-) locoregionally recurrent or metastatic breast cancer

 

Paloma-3 (Formerly A5481023)

What:  The Paloma-3 study is a multicenter, randomized, double blind, placebo controlled, Phase 3 clinical trial with the primary objective of demonstrating the superiority of PD-0332991 (Palbociclib) in combination with Fulvestrant (Faslodex®) over Fulvestrant alone in prolonging Progression Free Survival (PFS) in women with hormone receptor positive (ER/PR), HER2(-) locally recurrent or metastatic breast cancer whose disease progressed after prior endocrine therapy. The safety between the two treatment arms will also be compared.

Who: This study is designed for women who are 18 years or older with hormone receptor positive (ER/PR), HER2(-) locally recurrent or metastatic breast cancer whose disease progressed after prior endocrine therapy.

Why: This study is comparing the effects and demonstrating superiority between the two treatment arms in preventing further cancer growth. It will also study the safety of the study treatment.



Join Us:  To see if you, or someone you may know, fit the criteria for one of our breast cancer studies, please contact the Clinical Trials Coordinator at Northern Westchester Hospital: 914.666.1366, or click CONTACT US above.   

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Brain Tumor – Glioblastoma Multiforme Clinical Trials  New York 

DCVax-L

What:  The DCVax-L study is evaluating an experimental vaccine for its effectiveness in treating Glioblastoma brain tumors. 

Who:  This study is designed for patients diagnosed with a Glioblastoma tumor – a specific type of cancerous brain tumor.

Why:  The DCVax-L study is evaluating an experimental vaccine derived from a patient’s own white blood cells that is believed to work with the patient’s immune system to target brain cancer cells. 


NCT00892177 / N0872 CLOSED to new enrollment

What:  Phase I and Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined With Bevacizumab in Recurrent Glioblastoma.

Who:  This study is designed for men and women who are 18 years or older with histological confirmation of grade 3 or 4 glioblastoma multiforme (grade 4 astrocytoma) as determined by pre-registration central pathology review; Note: Variant gliosarcomas are eligible.

Why:  This randomized phase I/II trial (Phase I completed) is studying the side effects and best dose of dasatinib when given together with bevacizumab and to see how well it works compared to placebo in treating patients with recurrent or progressive high-grade glioma or glioblastoma multiforme.
 

Join Us:  To see if you, or someone you may know, fit the criteria for the brain tumor study, please contact the Clinical Trials Coordinator at Northern Westchester Hospital: 914.666.1366, or click CONTACT US above.   

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Prostate Cancer Clinical Trial New York

MEAL – Men's Eating and Living 

What:  The MEAL study, sponsored by the National Cancer Institute, focuses on whether a man's nutrition and diet can contribute towards the progression of prostate cancer.

Who:  The MEAL study is designed for men who have been diagnosed with prostate cancer and have been placed on active surveillance, also known as the watch and wait approach. These men have not had chemotherapy, radiation or surgery. 

Why:  The MEAL study is designed to test whether a high-vegetable diet will lower the risk for prostate cancer progression compared to a “standard” diet.  The MEAL study is crucial to our understanding of the possible relation between consumption of foods and food groups and the progression of prostate cancer.

Join Us:  To see if you, or someone you may know, fit the criteria for the MEAL study, please contact the Clinical Trials Coordinator at Northern Westchester Hospital: 914.666.1366, or click CONTACT US above.    

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Follicular Non-Hodgkin's Lymphoma Clinical Trials New York, HOMER OMB113676 and CALGB 50901

HOMER OMB113676

What:  A phase III randomized study that seeks to compare ofatumumab and rituximab in the treatment of follicular non-Hodgkin's lymphoma.

Who:  This study is designed for adults 18 years or older with follicular non-Hodgkin's lymphoma who have relapsed at least six months after completing their last prior treatment of rituximab-containing therapy.

WhyRituxan (rituximab) is the current standard of care for patients with slow-growing lymphomas, such as follicular non-Hodgkin's lymphoma. Although Rituxan is a highly targeted and well-tolerated lymphoma treatment, the remission rate is lower.  Ofatumumab has induced remissions in patients with similar conditions, but has not yet been studied in follicular lymphoma.  The HOMER study seeks to determine whether ofatumumab alone can achieve improved outcomes.

 

CALGB 50901 CLOSED to new enrollment

What:  The CALGB trial is a Phase II randomized trial comparing the use of high and low doses of ofatumumab for previously untreated patients with follicular non-Hodgkin’s lymphoma to determine whether higher or lower doses can achieve improved outcomes in patients with low-grade follicular NHL.

Who:  This study is designed for adults 18 years or older with follicular non-Hodgkin’s lymphoma who have been previously untreated. Those that are pregnant or nursing are not eligible.

Why:  Although not yet studied in follicular lymphoma, ofatumumab has induced remissions in patients with similar conditions resistant to other medications. The CALGB trial seeks to determine the effectiveness of ofatumumab in follicular non-Hodgkin’s lymphoma patients
 
Join Us:  To see if you, or someone you may know, fit the criteria for HOMER or CALGB studies in follicular non-Hodgkin's lymphoma, please contact the Clinical Trials Coordinator at Northern Westchester Hospital: 914.666.1366, or click CONTACT US above.   

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About The Clinical Trials Program at NWH

Joshua Fink, MD, is the Medical Director of the Clinical Trials Program at Northern Westchester Hospital, Mt. Kisco, NY.
Jonathan Goldberg, MD, is the Medical Director of the Cancer Clinical Trials at the Cancer Treatment and Wellness Center at Northern Westchester Hospital.

To learn more about NWH, take a virtual tour of the outstanding services available close to home at Northern Westchester Hospital.